Author

M. A. Lopez-Ramirez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. R. Gingras· 2 shared F. Lagarrigue· 2 shared A. Gingras· 1 shared A. Sharabi· 1 shared A. Valadez· 1 shared B. Gongol· 1 shared B. Tan· 1 shared C. Ballatore· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

A. R. Gingras

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs

M. Gilardi, R. Saddawi-Konefka, V. H. Wu, M. A. Lopez-Ramirez, Z. Wang, F. Soto, D. J. Steffen, M. Proietto, Z. Mikulski, H. Miki, A. Sharabi, D. Kupor, R. Rueda, D. P. Hollern, J. Wang, J. S. Gutkind

This study demonstrates that microneedle-mediated local delivery of anti-CTLA-4 antibody reduces immune-related adverse events while effectively treating oral squamous cell carcinoma.

bioRxiv · Dec 7, 2021Cancer Biology

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

F. Lagarrigue, B. Tan, Q. Du, Z. Fan, M. A. Lopez-Ramirez, A. R. Gingras, W. Qi, H. Sun

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

bioRxiv · Sep 22, 2021 · PreprintCell Biology

Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Kruppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells

M. A. Lopez-Ramirez, M. K. Haynes, P. Hale, K. Oukoloff, M. Bautista, B. Gongol, J. Y. Shyy, C. Ballatore, L. A. Sklar, A. R. Gingras

This study identifies inhibitors of the HEG1-KRIT1 interaction that increase KLF4/2 expression in endothelial cells, leading to upregulation of thrombomodulin and downregulation of thrombospondin.

bioRxiv · Aug 23, 2019 · PreprintBiochemistry

A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem

A. Gingras, F. Lagarrigue, M. Cuevas, M. Zorovich, A. Valadez, M. A. Lopez-Ramirez, N. Seban, W. McLaughlin, K. Ley, W. Kiosses, M. Ginsberg

The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.

bioRxiv · Apr 13, 2019Cell Biology