Author

A. Gingras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

F. Lagarrigue· 2 shared M. Ginsberg· 2 shared A. Valadez· 1 shared H. Lee· 1 shared H. Sun· 1 shared J. W. Fox· 1 shared K. Ley· 1 shared M. A. Lopez-Ramirez· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

F. Lagarrigue

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Author profile →

2 papers

Recent·Most cited

Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid Organs

H. Lee, H. Sun, F. Lagarrigue, J. W. Fox, N. E. Sherman, A. Gingras, M. Ginsberg

This study identifies Phostensin as a regulator of integrin activation in lymphocytes by stabilizing the MIT complex through Rap1 dephosphorylation, leading to lymphoid organ population and T cell-mediated colitis.

bioRxiv · Sep 24, 2021Immunology

A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem

A. Gingras, F. Lagarrigue, M. Cuevas, M. Zorovich, A. Valadez, M. A. Lopez-Ramirez, N. Seban, W. McLaughlin, K. Ley, W. Kiosses, M. Ginsberg

The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.

bioRxiv · Apr 13, 2019Cell Biology