Cell BiologybioRxiv
A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem
A. Gingras, F. Lagarrigue, M. Cuevas…·M. Ginsberg
The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.
DOI 10.1083/jcb.201810061