Author

F. Lagarrigue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Gingras· 2 shared H. Sun· 2 shared M. A. Lopez-Ramirez· 2 shared M. Ginsberg· 2 shared A. Diz-Munoz· 1 shared A. Metais· 1 shared A. R. Gingras· 1 shared A. Valadez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Gingras

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics.

P. Verdys, J. Rey Barroso, J. Vermeil, M. Bergert, T. Sanchez, A. Metais, T. Mangeat, E. Bellard, C. Bigot, J.-P. Girard, I. Maridonneau-Parini, C. Verollet, F. Lagarrigue, A. Diz-Munoz, J. Heuvingh, , R. Poincloux

This study shows that ezrin, radixin, and moesin are not required for macrophage migration or actin cortex mechanics, challenging their universal importance in these processes.

bioRxiv · Jul 27, 2023 · PreprintCell Biology

Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid Organs

H. Lee, H. Sun, F. Lagarrigue, J. W. Fox, N. E. Sherman, A. Gingras, M. Ginsberg

This study identifies Phostensin as a regulator of integrin activation in lymphocytes by stabilizing the MIT complex through Rap1 dephosphorylation, leading to lymphoid organ population and T cell-mediated colitis.

bioRxiv · Sep 24, 2021Immunology

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

F. Lagarrigue, B. Tan, Q. Du, Z. Fan, M. A. Lopez-Ramirez, A. R. Gingras, W. Qi, H. Sun

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

bioRxiv · Sep 22, 2021 · PreprintCell Biology

A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem

A. Gingras, F. Lagarrigue, M. Cuevas, M. Zorovich, A. Valadez, M. A. Lopez-Ramirez, N. Seban, W. McLaughlin, K. Ley, W. Kiosses, M. Ginsberg

The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.

bioRxiv · Apr 13, 2019Cell Biology