A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts
B. Zhang, S. Zhao, D. Yang, Y. Wu, Y. Xin, H. Cao, X.-P. Huang, X. Cai, W. Sun, N. Ye, Y. Xu, Y. Peng, S. Zhao, Z.-J. Liu, G. Zhong, , W. Shui
This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.
bioRxiv · Dec 22, 2019Biochemistry