Y. Xin

The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation

This paper identifies ABHD1 as a lysolipid lipase involved in lipid droplet formation through enzymatic and structural actions on the LD surface in Chlamydomonas.

Cell context-specific Synthetic lethality Prediction and Mechanism Analysis

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture

This study investigates how carotenoid assembly affects quinone diffusion and the structure of the reaction center-light harvesting complex in Roseiflexus castenholzii.

Thermophoresis of Molecules and Structures of different Sizes in Self-assembled Biomatrices

The paper studies thermophoresis of various biomolecules in self-assembled matrices, showing enhanced thermodiffusion due to surrounding network effects.

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

ACTIN Anchors the Highly Oligomeric DRP1 at Mitochondria-Sarcoplasmic Reticulum Contact Sites in Adult Murine Heart: Its Functional Implication

This study shows DRP1 clusters at mitochondria-SR contact sites via β-actin, maintaining mitochondrial quality control in adult hearts despite reduced DRP1 levels.

Rhodanese Rdl2 produces reactive sulfur species to scavenge hydroxyl radical and protect mitochondria

The paper identifies Rhodanese 2 (Rdl2) as critical for protecting mitochondria from hydroxyl radical damage in yeast by converting sulfur species into reactive sulfane sulfur.

DNA methylation affects pre-mRNA transcriptional initiation and processing in Arabidopsis

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

Genome engineering of Nannochloropsis with large deletions for constructing microalgal minigenomes

The paper develops a method to delete large genomic regions in Nannochloropsis oceanica, showing that non-essential regions can be removed without affecting key traits.

Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.

Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controls

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.