Cancer BiologybioRxiv
PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps
K. Cong, A. N. Kousholt, M. Peng…·S. Cantor
This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.
DOI 10.1016/j.molcel.2021.06.011