Jie Li

Interspecific hybrids reveal a deeply conserved nuclear role of EIF1A-family proteins in zygotic genome activation

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

S-Palmitoylation stabilizes OGT and the OGT-PPP1CC complex

This study identifies S-palmitoylation of OGT and shows it stabilizes OGT by preventing CMA degradation and enhances its interaction with PPP1CC and YAP.

PCC1 treatment reshapes ribosomal, lysosomal and membrane-lipid transcriptional programs in therapy-induced senescent human stromal cells

The paper analyzes the transcriptomic effects of PCC1 treatment on senescent human stromal cells, identifying gene expression changes in ribosomal, lysosomal, and membrane-lipid pathways.

Bone Lymphatic Endothelial Cells Form a Distinct Skeletal Population and Drive Skeletal Repair

The paper identifies bone lymphatic endothelial cells as a distinct population that drives skeletal repair and shows that their dysfunction contributes to mandibular diseases.

Plant growth forms shaping biodiversity patterns can guide conservation planning on the Qinghai-Tibet Plateau

The paper shows that plant growth forms influence biodiversity patterns on the Qinghai-Tibet Plateau, and prioritizing trees and climbers can effectively capture most diversity with minimal area.

Toward Precision Detection of Pyrazinamide Resistance: Critical Concentration Assessment and Rapid Molecular Method Validation

This study evaluates BMD and MeltPro MTB/PZA assays for detecting pyrazinamide resistance in RR-TB, finding MeltPro has high accuracy and BMD at 200 µg/mL shows better concordance with WGS.

Hippocampal Glucuronyl C5-epimerase promotes stress resilience by directly engaging PI3K through a non-enzymatic mechanism

This study identifies Glce as a non-enzymatic regulator of hippocampal dendritic integrity and stress resilience through direct activation of PI3K, revealing a novel mechanism in depression pathophysiology.

mChIP-seq for Multiplex and Multifactorial Epigenomic Profiling Uncovers Cancer-specific Histone Features in Cellular and Circulating Nucleosomes

The paper introduces mChIP-seq, a multiplex epigenomic profiling technology, and demonstrates its application in identifying cancer-specific histone features in both cellular and circulating nucleosomes.

Ferritin Nanoparticle-Based Indirect ELISA for Immunodominant Region Screening and B-cell Epitope Validation of African Swine Fever Virus

This study develops an EFNs-iELISA to screen and validate B-cell epitopes of ASFV using porcine sera, identifying 16 of 22 known epitopes and 7 new porcine-specific regions.

BMP-Smad1/9 signaling is required for PGC proliferation in zebrafish

This study shows BMP-Smad1/9 signaling is essential for zebrafish PGC proliferation and survival but not for their fate or migration.

Impact of Paraben on Uterine Collagen: An Integrated and Targeted Correlative Approach Using Second Harmonic Generation Microscopy, Nanoindentation, and Atomic Force Microscopy

This study examines how propylparaben affects uterine collagen structure and mechanics using SHG, Nanoindentation, and AFM, revealing disorganization and increased stiffness.

Next-Generation Mapping of the ACINUS-Mediated Alternative Splicing Machinery and Its Regulation by O-glycosylation in Arabidopsis

The paper maps the Arabidopsis alternative splicing machinery and identifies O-glycosylation regulators affecting splicing through ACINUS-dependent and -independent pathways.

Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain

The paper performs a deep mutational scan of CRX variants to classify clinical variants and reveals biochemical properties of the transcriptional effector domain.

Large-scale single-cell long-read genomics enables high-resolution microbiome profiling

The paper introduces CAP-seq, a single-cell genomics platform for microbiome analysis, demonstrating strain-level resolution and high genome recovery from microbial communities.

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

This paper uses untargeted mass spectrometry to analyze chemical changes in foods during preparation and storage, finding that some processes alter molecular composition while others primarily involve extraction.

Smad9 is a key player of follicular selection in goose via keeping the balance of LHR transcription

The paper investigates Smad9's role in goose follicular selection by showing it regulates LHR transcription, affecting egg production and hormone levels.