Cancer BiologybioRxivPreprint
DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers
Wenzhe Chen, George E. Maio, Xiao Chen…·Hening Lin
This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.