Daniela Bertinetti

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

This study uses focal molography to measure PKA-R-cAMP interactions in buffer and serum, showing favorable binding with enthalpic dominance in serum.

This study investigates the RIβ-L50R variant in NLPD-PKA, showing it causes misfolding, disrupts PKA holoenzyme assembly, and increases C-subunit nuclear translocation, with a potential therapeutic strategy to reduce dissociation.

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.