Friedrich W. Herberg

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

This study uses focal molography to measure PKA-R-cAMP interactions in buffer and serum, showing favorable binding with enthalpic dominance in serum.

This study investigates the RIβ-L50R variant in NLPD-PKA, showing it causes misfolding, disrupts PKA holoenzyme assembly, and increases C-subunit nuclear translocation, with a potential therapeutic strategy to reduce dissociation.

This study identifies three PDFs in tardigrades and shows they function as multifunctional hormones and neuromodulators involved in various physiological processes.

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.