G. Altes

In vivo intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancers.

This study shows that simultaneous deletion of Pten and p53 in endometrial epithelial cells leads to epithelial to mesenchymal transition and the formation of uterine carcinosarcomas in vivo.

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.