Polymerization force-regulated actin filament-Arp23 complex interaction dominates self-adaptive cell migrations
X. Chen, Y. Li, M. Guo, B. Xu, Y. Ma, H. Zhu, X.-Q. Feng
This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.
Proceedings of the National Academy of Sciences · Aug 28, 2023Peer-reviewedBiophysics