Loss of 7-Dehydrocholesterol Reductase-mediated cholesterol biosynthesis activates IRF3 and inhibits control of Mycobacterium marinum infection
Xiangyu Sui, Darryl JY Han, David M Costa…·Stefan H. Oehlers
This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.