Yan Hu

AAB-seq: An antigen-specific and affinity-readable high-throughput BCR sequencing method

AAB-seq identifies antigen-binding antibodies with affinity information from single-cell BCR sequencing in immunized mice.

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure

This study investigates immune and metabolic changes in individuals adapting to high altitude using single-cell transcriptomics and metabolomics, revealing immune activation and metabolic shifts linked to adaptation.

tBid mediated genetic ablation of connective tissue cells reveal their key regulatory function during limb regeneration in axolotls

The paper uses tBid-mediated ablation to show connective tissue cells are essential for positional identity and segmental patterning during axolotl limb regeneration.

Geoclimatic oscillations and ancient reciprocal adaptive introgression shape the evolutionary trajectories of threatened Coilia

This study reconstructs the evolutionary history of Coilia species, revealing ancient reciprocal introgression and its role in adaptation to geoclimatic changes.

Refining sequence-to-activity models by increasing model resolution

The paper improves sequence-to-activity models by incorporating ATAC-seq profiles, enhancing predictions of chromatin accessibility across immune cell types.

Trio deep-sequencing does not reveal unexpected mutations in Cas9-edited monkeys

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.