ImmunologybioRxiv
Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing
T.-H. Chang, Y. C. Gloria, M. J. Hellmann…·A. N. R. Weber
This study identifies CHIT1 as an enzyme that converts fungal chitin into oligomers sensed by TLR2, revealing a mammalian MAMP generation system similar to plants.
DOI 10.3389/fimmu.2025.1497174