Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis
K. Bruton, P. Spill, S. Vohra, O. Baribeau, S. Manzoor, S. Gadkar, M. Davidson, T. D. Walker, Y. Ellenbogen, A. Florescu, J. Wen, D. K. Chu, S. Waserman, R. Jimenez-Saiz, S. Epelman, , M. Jordana
The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.
bioRxiv · Mar 4, 2020 · PreprintImmunology