Author

S. Gadkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. Bruton· 3 shared M. Jordana· 3 shared S. Waserman· 3 shared E. Grydziuszko· 2 shared J. F. Koenig· 2 shared J. Wen· 2 shared R. Jimenez-Saiz· 2 shared T. Walker· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

K. Bruton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathogenic IgE-fated memory B cell responses retain functional plasticity

K. Bruton, A. Phelps, A. Ariaz, A. Fang, T. Walker, J. Wen, S. S. Khavkine-Binstock, D. Della Libera, O. Mann-Delany, N. P. H. Knudsen, S. Gadkar, E. Grydziuszko, J. F. Koenig, A. Gagnon, S. Waserman, , M. Jordana

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.

bioRxiv · Nov 28, 2023Immunology

Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens

J. F. Koenig, A. K. Wade-Vallance, R. Jimenez-Saiz, K. Bruton, S. Gadkar, E. Grydziuszko, T. Walker, M. E. Gordon, S. Waserman, M. Jordana

This study shows that sequential switching through IgG1 is not essential for IgE affinity, anaphylaxis, or allergic memory in food allergies.

bioRxiv · May 27, 2023 · PreprintImmunology

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

K. Bruton, P. Spill, S. Vohra, O. Baribeau, S. Manzoor, S. Gadkar, M. Davidson, T. D. Walker, Y. Ellenbogen, A. Florescu, J. Wen, D. K. Chu, S. Waserman, R. Jimenez-Saiz, S. Epelman, , M. Jordana

The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.

bioRxiv · Mar 4, 2020 · PreprintImmunology