Author

S. Epelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 2 Organism:human· 2 Research Focus:clustering· 1

Frequent Co-Authors

H. Hamidzada· 2 shared A. B. Kim· 1 shared A. Bredemeyer· 1 shared A. Diwan· 1 shared A. Florescu· 1 shared A. Kovacs· 1 shared A. Meinhardt· 1 shared A. Momen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

H. Hamidzada

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells

I. Fernandes, S. Funakoshi, H. Hamidzada, S. Epelman, G. Keller

The paper models cardiac fibroblast heterogeneity using human pluripotent stem cell-derived epicardial cells and shows high heterogeneity similar to human heart fibroblasts.

bioRxiv · Oct 22, 2023Cell Biology

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease

Q. Pan, P. Yan, A. B. Kim, Q. Xiao, G. Pandey, H. Haecker, S. Epelman, A. Diwan, J.-M. Lee, C. J. DeSelm

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.

bioRxiv · Apr 28, 2023 · PreprintImmunology

The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

C. Pleuger, D. Ai, M. L. Hoppe, L. T. Winter, D. Bohnert, D. Karl, S. Guenther, S. Epelman, C. Kantores, M. Fijak, S. Ravens, R. Middendorff, J. U. Mayer, K. L. Loveland, M. P. Hedger, , A. Meinhardt

The paper identifies region-specific immune cell subsets in the murine epididymis using scRNA-seq, revealing distinct immunological environments along the duct.

bioRxiv · Jun 13, 2022Immunology

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

P. Chiaranunt, K. Burrows, L. Ngai, E. Y. Cao, S. L. Tai, H. Hamidzada, A. Wong, M. Kuypers, T. Despot, A. Momen, S. M. Lim, T. Mallevaey, T. Conway, H. Imamura, S. Epelman, A. Mortha

The paper identifies a microbial energy metabolism-driven niche in tertiary lymphoid organs that supports intestinal macrophage development via CSF2 and ILC3 activity.

bioRxiv · Mar 23, 2022 · PreprintImmunology

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

N. R. Wong, J. Mohan, B. Kopecky, S. Guo, L. Du, J. Leid, O. Dmytrenko, H. Luehmann, G. Bajpai, L. Ewald, L. Bell, N. Patel, I. Lokshina, A. Bredemeyer, C. J. Weinheimer, , K. J. Lavine

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

bioRxiv · Jan 28, 2021Immunology

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

K. Bruton, P. Spill, S. Vohra, O. Baribeau, S. Manzoor, S. Gadkar, M. Davidson, T. D. Walker, Y. Ellenbogen, A. Florescu, J. Wen, D. K. Chu, S. Waserman, R. Jimenez-Saiz, S. Epelman, , M. Jordana

The paper uses single-cell RNA-sequencing to identify IL-4/IL-13 as critical for IgE recall in peanut allergy and shows blocking this pathway prevents anaphylaxis.

bioRxiv · Mar 4, 2020 · PreprintImmunology