Author

Y. Hinze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Pouikli· 2 shared C. Nikopoulou· 2 shared K. Folz-Donahue· 2 shared M. Maleszewska· 2 shared P. Giavalisco· 2 shared P. Tessarz· 2 shared S. Parekh· 2 shared A. C. Hausen· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

A. Pouikli

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Author profile →

3 papers

Recent·Most cited

Hypoxia promotes osteogenesis via regulation of the mito-nuclear communication

A. Pouikli, M. Maleszewska, S. Parekh, C. Nikopoulou, J.-J. Bonfiglio, C. Mylonas, T. Sandoval, A.-L. Schumacher, Y. Hinze, I. Matic, P. Tessarz

This study shows that high oxygen levels impair osteogenesis in MSCs by disrupting mito-nuclear communication through chromatin compaction and histone hypo-acetylation, which can be reversed by acetate supplementation.

bioRxiv · Feb 26, 2022 · PreprintCell Biology

P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesity

A. Sieben, A. C. Hausen, P. Klemm, A. Jais, C. Heilinger, J. Alber, K. Folz-Donahue, L. Schumacher, J. Altmüller, M. Franitza, P. Giavalisco, Y. Hinze, S. Brodesser, C. Kukat, S. Theurich, J. C. Brüning

This study shows that blocking P2Y6R in NK cells improves insulin sensitivity in obese mice by reducing adipose tissue inflammation and glucose production.

bioRxiv · Jun 23, 2021 · PreprintImmunology

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

A. Pouikli, S. Parekh, M. Maleszewska, M. Baghdadi, I. Tripodi, C. Nikopoulou, K. Folz-Donahue, Y. Hinze, A. Mesaros, P. Giavalisco, R. Dowell, L. Partridge, P. Tessarz

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

bioRxiv · Apr 2, 2020 · PreprintCell Biology