S. Parekh

Hypoxia promotes osteogenesis via regulation of the mito-nuclear communication

This study shows that high oxygen levels impair osteogenesis in MSCs by disrupting mito-nuclear communication through chromatin compaction and histone hypo-acetylation, which can be reversed by acetate supplementation.

Single-cell resolution unravels spatial alterations in metabolism, transcriptome and epigenome of ageing liver

The paper investigates age-related spatial changes in metabolism, transcriptome, and epigenome in the murine liver using multi-omics approaches.

Single organoid RNA-sequencing reveals high organoid-to-organoid variability

This study uses RNA-seq to show that organoids vary significantly between individuals within a culture, but not between batches, suggesting microenvironmental effects drive this variability.

Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers

The paper investigates how solvent compatibility affects phase behavior in binary solutions of multivalent polymers, showing that it modulates isothermal liquid-liquid phase separation.

Structural control of fibrin bioactivity by mechanical deformation

This study shows that mechanical deformation of fibrin induces structural changes that affect its biochemistry and platelet interactions, revealing a mechano-chemical feedback loop.

Patient Similarity Network of Multiple Myeloma Identifies Patient Sub-groups with Distinct Genetic and Clinical Features

The paper introduces MM-PSN, a multi-omics patient similarity network for Multiple Myeloma, identifying three broad groups and twelve sub-groups with distinct genetic and clinical features.

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

Quantitative mapping of triacylglycerol chain length and saturation using broadband CARS microscopy

This paper introduces a method to quantitatively analyze triacylglycerol composition in lipid droplets using broadband CARS microscopy, enabling rapid and accurate in situ analysis.