Author

R. Dowell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Mesaros· 1 shared A. Pierce· 1 shared A. Pouikli· 1 shared B. Sanford· 1 shared C. Nikopoulou· 1 shared D. Wang· 1 shared E. Danis· 1 shared F. M. Walker· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Mesaros

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

F. M. Walker, L. Martin Sobral, E. Danis, B. Sanford, I. Balakrishnan, D. Wang, A. Pierce, S. D. Karam, N. J. Serkova, N. K. Foreman, S. Venkataraman, R. Dowell, R. Vibhakar, N. A. Dahl

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

A. Pouikli, S. Parekh, M. Maleszewska, M. Baghdadi, I. Tripodi, C. Nikopoulou, K. Folz-Donahue, Y. Hinze, A. Mesaros, P. Giavalisco, R. Dowell, L. Partridge, P. Tessarz

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

bioRxiv · Apr 2, 2020 · PreprintCell Biology