ImmunologybioRxiv
Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation
K. Nagata, D. Ando, T. Ashikari…·C. Nishiyama
This study shows that butyrate and valerate reduce IgE-mediated mast cell activation by enhancing PGE2 release and GPR109A signaling, while niacin also alleviates anaphylaxis through similar mechanisms.
DOI 10.4049/jimmunol.2300188