Author

Y. Kochi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Yamamoto· 3 shared A. Suzuki· 2 shared K. Fujio· 2 shared K. Ishigaki· 2 shared M. Ota· 2 shared S. Sumitomo· 2 shared S. Tanaka· 2 shared A. Kumanogoh· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

K. Yamamoto

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

C. Ono, S. Tanaka, K. Myouzen, T. Iwasaki, M. Ueda, Y. Oda, K. Yamamoto, Y. Kochi, Y. Baba

This study shows that upregulated Fcrl5 disrupts B cell anergy, leading to autoimmunity by activating autoreactive B cells and exacerbating autoimmune disease models.

bioRxiv · Jul 20, 2023 · PreprintImmunology

CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

Y. Mitsui, T. Suzuki, K. Kuniyoshi, J. Inamo, K. Yamaguchi, M. Komuro, J. Watanabe, M. Edamoto, S. Li, T. Kouno, S. Oba, T. Hosoya, S. Koyama, N. Sakaguchi, D. M. Standley, , T. Satoh

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

bioRxiv · Sep 30, 2022 · PreprintImmunology

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

Y. Takeshima, Y. Iwasaki, M. Nakano, Y. Narushima, M. Ota, Y. Nagafuchi, S. Sumitomo, T. Okamura, K. B. Elkon, K. Ishigaki, A. Suzuki, Y. Kochi, K. Yamamoto, K. Fujio

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

bioRxiv · Oct 8, 2021 · PreprintImmunology

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

H. Tsuchiya, M. Ota, S. Sumitomo, K. Ishigaki, A. Suzuki, T. Sakata, Y. Tsuchida, H. Inui, J. Hirose, Y. Kochi, Y. Kadono, K. Shirahige, S. Tanaka, K. Yamamoto, K. Fujio

This study analyzes multi-omics data from activated synovial fibroblasts to identify genetic risk factors and potential drug targets for rheumatoid arthritis.

bioRxiv · Jun 3, 2020Immunology