M. Ueda

A viscoelastic-plastic deformation model of hemisphere-like tip growth in Arabidopsis zygotes

The paper develops a viscoelastic-plastic model to simulate tip growth in Arabidopsis zygotes and identifies non-dimensional parameters that maintain a hemisphere-like shape.

Deep learning-based cytoskeleton segmentation for accurate high-throughput measurement of cytoskeleton density

This study uses deep learning to segment cytoskeleton structures in plant cells, improving density measurements compared to traditional methods.

Brassinosteroids function as the plant male and female reproductive hormone coordinating gene expression.

This study shows that brassinosteroids (BRs) function as reproductive hormones in Arabidopsis, regulating gene expression in both male and female reproductive tissues during fertilization.

Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana.

The paper identifies downstream metabolites of cis-OPDA as noncanonical bioactive jasmonates in Arabidopsis thaliana that function independently of the JA-Ile-COI1-JAZ signaling pathway.

HD-ZIP IV genes are essential for embryo initial cell polarization in the radial axis initiation in Arabidopsis

This study identifies HD-ZIP IV genes as essential for radial axis formation in Arabidopsis by regulating apical cell polarization and division orientation.

Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against ATL

This study shows that mismatch between viral antigen epitopes and T-cell responses in HTLV-1 infection may reduce immunotherapy effectiveness against ATL.

Single-molecule tracking-based drug screening

This study uses single-molecule tracking to screen FDA-approved drugs for effects on EGFR mobility and clustering, identifying both known and novel compounds that impact EGFR function.

Surface-engineered extracellular vesicles to modulate antigen-specific T cell expansion for cancer immunotherapy

The paper develops antigen-presenting extracellular vesicles (AP-EVs) engineered to enhance T cell expansion and anticancer immunity through combined immunotherapy.

Comprehensive and quantitative analysis of intracellular structure polarization at the apical-basal axis in elongating Arabidopsis zygotes

The paper quantitatively analyzes intracellular structure polarization along the apical-basal axis in Arabidopsis zygotes and links compartmentalization to asymmetric cell division positioning.

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

This study shows that upregulated Fcrl5 disrupts B cell anergy, leading to autoimmunity by activating autoreactive B cells and exacerbating autoimmune disease models.

Origami-based growing tube model for reproducing shell shapes

This study uses origami to create physical models of shell shapes based on a mathematical growing tube model, enabling hands-on understanding of shell morphology parameters.

Conjugation of cis-OPDA with amino acids is a conserved pathway affecting cis-OPDA homeostasis upon stress responses

This study identifies OPDA-amino acid conjugates as a conserved mechanism for regulating cis-OPDA homeostasis in plants during stress responses.

A dynamic partitioning mechanism polarizes membrane protein distribution

This study identifies a dynamic partitioning mechanism that explains asymmetric membrane protein distribution during signaling events.

Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima

The paper identifies a male-killing-associated bacteriophage WO in Wolbachia strains of Homona magnanima and proposes a mechanism for male-killing evolution.

Chemical screen of Arabidopsis zygote and proteomics in tobacco BY-2 cells identify general plant cell division inhibitors

The paper identifies two plant cell division inhibitors through chemical screening in Arabidopsis zygotes and validates their effects in tobacco BY-2 cells and multiple plant species.

Membrane cholesterol interferes with tyrosine phosphorylation but facilitates the clustering and signal transduction of EGFR

This study shows that cholesterol affects EGFR mobility, clustering, and signaling by altering membrane subdomain structure and lipid composition.

Small Vessel Diseases: 3D Characteristics of the Vasculature and White Matter

This study examines 2D and 3D vascular and white matter changes in CADASIL, HTRA1-AD, and sSVD using light-sheet fluorescence microscopy, revealing distinct patterns of degeneration.

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

This study shows that ESRG, a HERV-H-driven lncRNA in human pluripotent stem cells, is not required for maintaining or reprogramming pluripotency.

Identification of a Putative Sensor Protein Involved in Regulation of Vesicle Production by a Hypervesiculating Bacterium, Shewanella vesiculosa HM13

This study identifies HM1275 as a sensor protein regulating vesicle production and biofilm suppression in Shewanella vesiculosa HM13 in response to lysine.

Dynamics of the cell fate specifications during female gametophyte development in Arabidopsis

This study visualizes female gametophyte development in Arabidopsis and identifies when and how cell fates are determined during its formation.

A new role for histone demethylases in the maintenance of plant genome integrity

This study identifies ELF6 and REF6 as JMJ histone demethylases in Arabidopsis that maintain H3K27me3 and H3K27me1 homeostasis, preventing epigenetic imprints and transposon activation during sexual reproduction.

Excitable dynamics of Ras triggers self-organized PIP3 signaling for spontaneous cell migration

The paper shows Ras-GTP excitation drives self-organized PIP3 signaling waves that enable spontaneous cell migration without external cues.

Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors

The paper uses single-molecule imaging to assess ligand effects on GPCRs by monitoring diffusion dynamics on the cell surface, showing that diffusion coefficients correlate with receptor activity.