Cancer BiologybioRxiv
Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models
S. Jacob, T. H. Turner, J. Cai…·A. C. Faber
The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.
DOI 10.1093/pnasnexus/pgac232