J. Cai

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

The Microbiome and Metatranscriptome of a Panel from the Sarracenia Mapping Population Reveal Complex Assembly and Function Involving Host Influence.

This study analyzes the microbiome and metatranscriptome of Sarracenia species to reveal host-influenced community structure and functional convergence.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Enhancements in squid retinal responses to change of polarizations in a caustic shallow water

This study examines squid retinal responses to polarized light changes in a caustic environment, finding enhanced neural activity to dynamic polarization shifts.

Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis.

This study identifies nuclear roles for testis-specific ACTL7A and ACTL7B in chromatin regulation during spermiogenesis, supported by in vivo data and AI-enhanced in silico modeling.

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems

This study shows bacteria have a complete ubiquitination pathway similar to eukaryotes, with structural and functional parallels to eukaryotic systems.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex

The paper determines the crystal structure of a Cse4 peptide bound to the Okp1-Ame1 heterodimer in budding yeast, revealing key interactions essential for centromere recognition.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Endothelial-specific reduction in Arf6 impairs insulin-stimulated vasodilation and skeletal muscle blood flow resulting in systemic insulin resistance

This study shows that reducing Arf6 in endothelial cells impairs insulin-stimulated vasodilation and causes systemic insulin resistance.

Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1)

This study identifies ESYT1 as an intracellular modulator of GPR133 signaling, showing that Ca2+ levels influence their interaction and affect cAMP levels in glioblastoma cells.

Genetics of Latin American Diversity (GLAD) Project: insights into population genetics and association studies in recently admixed groups in the Americas

The GLAD Project compiles genome-wide data from 54,077 Latin Americans and develops tools for ancestry matching and statistical software evaluation in admixed populations.

Rapid generation of CD19 CAR-T Cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia

This study develops a method using minicircle DNA to rapidly generate CD19 CAR-T cells that are effective and safe, avoiding genomic integration risks.

The translational role of SOS1 in colorectal cancer

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

Functional characterization of multidomain protein Vip3Aa from Bacillus thuringiensis reveals a strategy to increase its insecticidal potency

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

Aging-related iron deposit prevents the benefits of HRT from late postmenopausal atherosclerosis

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages

This study shows that the LRR domain of NLRP3 is essential for its inflammasome activation in macrophages by enabling self-association, oligomerization, and interaction with NEK7.

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.

Multifaceted effects of variable biotic interactions on population stability in complex interaction webs

This study examines how variability in biotic interactions affects population stability in response to pesticide application in freshwater communities.

Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly

The paper identifies multi-site phosphorylation of Mif2/CENP-C as essential for inner kinetochore assembly and accurate chromosome segregation in yeast.

Assessment of Plasmodium falciparum infection and fitness of genetically modified Anopheles gambiae aimed at mosquito population replacement

The paper assesses the susceptibility of genetically modified Anopheles gambiae to Plasmodium falciparum infection and evaluates the impact of Scorpine expression on mosquito fitness.

Construction of a solid Cox model for AML patients based on multiomics bioinformatic analysis

This study constructs a prognostic model for AML using multiomics data to identify immune-related biomarkers and classify patients into subtypes with different survival outcomes.

Systematic analysis of the R2R3-MYB family of transcription factors in Camellia sinensis: evidence for species-specific catechin biosynthesis regulation

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

Environment-Dependent Switch between Two Immune Systems against Ralstonia solanacearum Infections in Pepper

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health

The paper compares gut microbiomes of East Asian and White individuals in the same geographic area, finding ethnic differences linked to metabolic health and independent of diet.