BiochemistrybioRxiv
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
M. Baidya, M. Chaturvedi, H. Dwivedi-Agnihotri…·A. K. Shukla
This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.
DOI 10.1038/s41467-022-32386-x