Author

D. Devost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

T. E. Hebert· 2 shared T. Hebert· 2 shared A. C. Hanyaloglu· 1 shared A. F. A. Keszei· 1 shared A. K. Shukla· 1 shared A. Ranjan· 1 shared A. X. Ji· 1 shared A. Zhai· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

T. E. Hebert

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Author profile →

4 papers

Recent·Most cited

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

S. Z. Hanif, C. C. Au, I. Torregroza, C. Kutz, S. Jannath, T. Fabiha, B. Bhinder, M. Washburn, D. Devost, S. Liu, P. Bhardwaj, T. Evans, P. K. Anand, R. Tarran, S. Palikhe, , K. A. Brown

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

bioRxiv · Jul 22, 2024 · PreprintCancer Biology

Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex

D. M. Nguyen, D. H. Rath, D. Devost, D. Petrain, R. Rizk, A. X. Ji, N. Narayanan, D. Yong, A. Zhai, D. A. Kuntz, M. U. Q. Mian, N. C. Pomroy, A. F. A. Keszei, S. Benlekbir, M. T. Mazhab-Jafari, , G. G. Prive

The paper presents the cryo-EM structure of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex, revealing its dynamic architecture and mechanism for ubiquitylating Gβγ.

bioRxiv · Sep 20, 2023 · PreprintBiochemistry

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

M. Baidya, M. Chaturvedi, H. Dwivedi-Agnihotri, A. Ranjan, D. Devost, Y. Namkung, T. M. Stepniewski, S. Pandey, M. Baruah, B. Panigrahi, J. Maharana, R. Banerjee, J. Selent, S. Laporte, T. E. Hebert, A. K. Shukla

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

bioRxiv · Jan 11, 2022Biochemistry

Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

C. Toufaily, J. Fortin, C. A. I. Alonso, E. Lapointe, X. Zhou, Y. Santiago-Andres, Y.-F. Lin, Y. Cui, Y. Wang, D. Devost, F. Roelfsema, F. Steyn, A. C. Hanyaloglu, T. Hebert, T. Fiordelisio, , D. J. Bernard

This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.

bioRxiv · Sep 13, 2021Physiology