A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor
T. Khazma, Y. Golan-Vaishenker, J. Guez-Haddad, A. Grossman, R. Sain, A. Plotnikov, R. Zalk, A. Yaron, M. Hons, Y. Opatowsky
The paper identifies a new inhibitor of SARM1 that stabilizes an octamer conformation and induces a meta-stable duplex structure, revealing an additional auto-inhibition mechanism.
bioRxiv · Mar 2, 2022 · PreprintBiochemistry