Author

A. Plotnikov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

H. Barr· 3 shared N. London· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared A. C. Greenwald· 1 shared A. Douangamath· 1 shared A. G. B. Simpson· 1 shared A. Grossman· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

H. Barr

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

D. Algranati, R. Oren, B. Dassa, L. Fellus-Alyagor, A. Plotnikov, H. Barr, A. Harmelin, N. London, G. Ron, N. Furth, E. Shema

This study investigates dual targeting of HDACs and MYC in H3-K27M pediatric gliomas, showing synergistic effects in reducing cell viability and tumor growth.

bioRxiv · Feb 5, 2024Cancer Biology

A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor

T. Khazma, Y. Golan-Vaishenker, J. Guez-Haddad, A. Grossman, R. Sain, A. Plotnikov, R. Zalk, A. Yaron, M. Hons, Y. Opatowsky

The paper identifies a new inhibitor of SARM1 that stabilizes an octamer conformation and induces a meta-stable duplex structure, revealing an additional auto-inhibition mechanism.

bioRxiv · Mar 2, 2022 · PreprintBiochemistry

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

M. Su, T. Fleisher, I. Grosheva, M. B. Horev, M. Olszewska, B. Haim, A. Plotnikov, S. Carvalho, Y. Moskovitz, M. Minden, N. Chapal-Ilani, E. P. Papapetrou, N. Dezorella, T. Cheng, N. Kaushansky, , L. I. Shlush

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

G. S. Kinker, A. C. Greenwald, R. Tal, Z. Orlova, M. S. Cuoco, J. M. McFarland, A. Warren, C. Rodman, J. A. Roth, S. A. Bender, B. Kumar, J. W. Rocco, P. A. Fernandes, C. C. Mader, H. Keren-Shaul, , I. Tirosh

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology

Ecological and evolutionary patterns in the enigmatic protist genus Percolomonas (Heterolobosea; Discoba) from diverse habitats

D. V. Tikhonenkov, S. H. Jhin, Y. Eglit, K. Miller, A. Plotnikov, A. G. B. Simpson, J. S. Park

The paper analyzes 18S rRNA gene sequences from seven Percolomonas cosmopolitus-like strains from diverse salinities, revealing cryptic species and ecological specialization.

bioRxiv · Apr 17, 2019Microbiology

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry