Author

M. Sporny

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Yaron· 1 shared C. Mim· 1 shared J. Guez-Haddad· 1 shared M. Dessau· 1 shared M. Hons· 1 shared M. N. Isupov· 1 shared R. Zalk· 1 shared T. Khazma· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Yaron

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1 paper

Recent·Most cited

BiochemistrybioRxivAug 5, 2020

The Structural Basis for SARM1 Inhibition, and Activation Under Energetic Stress

M. Sporny, J. Guez-Haddad, T. Khazma…·Y. Opatowsky

This paper presents cryo-EM structures of SARM1 showing how NAD+ inhibits its NADase activity and how NAD+ depletion activates it, leading to cell death.

DOI 10.7554/elife.62021

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