Author

J. Guez-Haddad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Yaron· 2 shared M. Hons· 2 shared R. Zalk· 2 shared T. Khazma· 2 shared Y. Opatowsky· 2 shared A. Grossman· 1 shared A. Plotnikov· 1 shared C. Mim· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

A. Yaron

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 2, 2022

A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor

T. Khazma, Y. Golan-Vaishenker, J. Guez-Haddad…·Y. Opatowsky

The paper identifies a new inhibitor of SARM1 that stabilizes an octamer conformation and induces a meta-stable duplex structure, revealing an additional auto-inhibition mechanism.

DOI 10.1101/2022.03.02.482641

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivAug 5, 2020

The Structural Basis for SARM1 Inhibition, and Activation Under Energetic Stress

M. Sporny, J. Guez-Haddad, T. Khazma…·Y. Opatowsky

This paper presents cryo-EM structures of SARM1 showing how NAD+ inhibits its NADase activity and how NAD+ depletion activates it, leading to cell death.

DOI 10.7554/elife.62021

mousecryo-EM

𝕏 PostBluesky