BiophysicsbioRxiv
The nucleotide addition cycle of the SARS-CoV-2 polymerase
S. C. Bera, M. Seifert, R. Kirchdoerfer…·D. Dulin
This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.
DOI 10.1016/j.celrep.2021.109650