C. E. Cameron

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

This study elucidates the biochemical mechanism of enteroviral 2C protein's ATPase activity, showing RNA stimulates ATP hydrolysis via a two-step binding mechanism.

Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease

This study investigates how SARS-CoV-2's ExoN enzyme processes RNA and identifies modifications that block its activity, offering potential for new antiviral strategies.

IRES-independent, eIF2A/eIF2D-dependent translation of the enterovirus genome

This study shows that enterovirus genome recombination depends on eIF2A/eIF2D-dependent translation, not IRES-mediated translation, and explains non-replicative recombination and RNA persistence.

The nucleotide addition cycle of the SARS-CoV-2 polymerase

This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses

This study shows that a ribonucleotide analogue induces copy-back RNA synthesis, a new mechanism to combat RNA viruses by promoting defective viral genomes.

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases.

This study uses temperature-controlled magnetic tweezers to compare replication kinetics of RdRps from three RNA viruses, finding temperature-dependent activation differences.

More than efficacy revealed by single-cell analysis of antiviral therapeutics

This study uses single-cell analysis to evaluate antiviral therapeutics, revealing efficacy and insights into drug resistance evolution and viral lifecycle impact.

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

Hijacking of Multiple Phospholipid Biosynthetic Pathways and Induction of Membrane Biogenesis by a Picornaviral 3CD Protein

This paper shows that a picornaviral 3CD protein induces multiple phospholipid biosynthetic pathways and membrane biogenesis by hijacking cellular machinery.

The RNA-binding site of poliovirus 3C protein doubles as a phosphoinositide-binding domain

This study identifies a dual function in poliovirus 3C protein, showing it binds both RNA and phosphoinositides, with PIP binding mediated by residues also involved in RNA binding.

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

The paper identifies sequences and structural requirements for efficient transcription from the first heavy-strand promoter in mtDNA, highlighting the role of TFAM's carboxy-terminal tail and HVR3.