Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma
H. Zhang, L.-n. Qin, Q.-q. Li, T. Wu, L. Zhang, K.-w. Wang, S.-b. Cheng, Y. Shi, Y.-q. Feng, J.-x. Han, Y.-n. Li, Z.-y. Li, H.-j. Liu, T. Sun
This study shows vitamin D reduces ecDNA in hepatocellular carcinoma by stabilizing DNase1L3 via its transporter GC, leading to tumor suppression.
bioRxiv · Aug 30, 2023 · PreprintCancer Biology