A. Ivanov

Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization

This study identifies beta2-adrenergic signaling as a key driver of bone healing by enhancing callus neovascularization, with implications for therapeutic strategies and the risks of beta-blockers.

Highly multiplexed detection of microRNAs, proteins and small molecules using barcoded molecular probes and nanopore sequencing

This paper develops a rapid, low-cost method for detecting multiple blood biomarkers using barcoded molecular probes and nanopore sequencing, demonstrating detection from human serum without extraction or amplification.

Structural insights into 3Fe-4S ferredoxins diversity in M.tuberculosis highlighted by a first redox complex with P450.

The paper solves the structures of 3Fe-4S ferredoxins from M. tuberculosis and their complex with CYP143, revealing structural and functional insights into redox interactions.

Learning the shape of protein micro-environments with a holographic convolutional neural network

This paper introduces H-CNN, a machine learning model that predicts mutation impacts on protein function using structural and evolutionary data.

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

Velcro-like mannose and slime-like sialic acid interactions guide self- adhesion and aggregation of virus N-glycan shields

This study investigates how slime-like and Velcro-like interactions between sialic acid and mannose residues in N-glycan shields on viruses influence self-adhesion and aggregation.

Defective photosynthetic adaptation mechanism in winter restricts the introduction of overwintering plant to high latitudes

This study compares photosynthetic adaptability of native and introduced overwintering species in winter, finding introduced species have lower CO2 fixation capacity and higher photodamage.

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.