Yi Li

The paper identifies a synonymous mutation in IGF-1 that reduces milk triacylglycerol containing medium-chain fatty acids in mice and pigs, revealing its molecular mechanism.

This paper constructs a unified transcriptional landscape of breast cancer using bulk RNA-seq data from multiple cohorts, identifying subtype and microenvironmental programs associated with therapeutic resistance.

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

The paper integrates multi-omics QTL and GWAS data to identify 123 novel biomarkers for lung cancer and reveals cross-omics regulatory pathways.

This study investigates the role of NRF2 in vascular calcification and aging, finding that NRF2 dysfunction contributes to vascular smooth muscle cell senescence and calcification, with ID2 as a downstream regulator.

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

This study demonstrates the successful production of genome-edited sperm from a phylogenetically distant fish species using cross-subfamily spermatogonial stem cell transplantation.