NeurosciencebioRxivPreprint
α2A-AR-Kv dysfunction drives LC hyperactivity and early sleep disturbance in amyloidogenic mice
Yi-Ci Zhang, Xueting Zhang, P. Chen…·Kaiwen He
This study identifies LC hyperactivity driven by α2A-AR and Kv channel dysfunction as a cause of early sleep disruption in 5xFAD mice.
DOI 10.1101/2025.09.26.678734