Michael Mülleder

The paper creates a proteoform-resolved atlas of the human plasma proteome, revealing extensive proteoform diversity and highlighting discrepancies between proteomic platforms.

The paper investigates how anesthetic exposure affects brain energy metabolism in an Alzheimer's model, showing reduced oxidative metabolism and worsened potassium regulation in diseased tissue.

The paper shows lipid chlorination by MPO-derived hypochlorous acid enables NE release from granules, initiating NETosis.

This paper develops a microbial platform to study Rubisco oxygenase activity in vivo by linking it to bacterial growth, enabling genetic screening and evolution of enzyme variants.

This study identifies Bro1 as a central integrator linking TOR signalling to metabolic adaptation and longevity in fission yeast.

This study compares host metabolic and signaling responses to SARS-CoV-2 variants, finding that Omicron causes a more restrained response compared to pre-Omicron variants.

This study shows that liver viscosity decreases before fibrosis in a mouse model of MASH, indicating it as a potential early biomarker.

This study uses proteomics to analyze glucose-stimulated insulin secretion in rat beta cells, finding that fatty acid metabolism plays a key role in the process.

The paper quantifies yeast cell responses to varying metal ions, revealing widespread proteomic and genetic impacts and common metal responsiveness properties.

This study examines how bacterial proteomes and metabolomes change in response to interspecies interactions in gut microbiota co-cultures, revealing extensive molecular reorganization and emergent metabolic pathways.

This study shows that amino acid sequences determine protein abundance by affecting conformational stability and synthesis cost, using deep learning and yeast experiments.

The paper links genome to proteome in yeast progeny to identify variants controlling proteome diversity and predict their fitness effects under stress.

The paper quantifies proteomic effects of aneuploidy in natural yeast isolates, finding chromosome-wide dosage compensation in the proteome but not transcriptome.

The paper quantifies transcriptomes and proteomes across 942 yeast isolates, showing weak correlation between mRNA and protein levels and distinct genetic control mechanisms.

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.

The paper records proteomes for non-essential gene knock-outs in yeast to uncover principles of protein expression and annotate gene function.

The paper shows that Sema7A and Sema4D heterodimerization is essential for membrane targeting and neocortical wiring, with a mutation in Sema4D causing epilepsy.

The paper shows yeast cells can cooperatively compensate for methionine auxotrophy by using a new homocysteine synthase, HSU1, to re-assimilate hydrogen sulfide.

The paper demonstrates improved proteomic depth using DIA-NN and FragPipe for dia-PASEF data, achieving higher sensitivity and quantification in complex samples.

The paper quantifies DNA modifications across diverse organisms and finds they are common in bacteria and higher eukaryotes but rare in yeast and insects.

OxoScan-MS enables sensitive and scalable glycoproteome profiling of plasma samples, revealing differential glycosylation in severe COVID-19 patients.

This study uses ribosome profiling to show that oxidative stress in fission yeast causes ribosome stalling on tryptophan codons due to reduced charged tRNA-Tryptophan, revealing a novel role for tRNA availability in stress response.

The paper identifies a natural variant in fission yeast Pyk1 that reduces glycolytic flux, increases respiration, and enhances oxidative-stress resistance but decreases growth.

The paper uses a yeast model to analyze multi-omic data from OPTN overexpression, finding distinct genetic and metabolic responses to different ALS-linked genes.