Yun-Jeong Choe

The paper shows FDA-approved PDE4 inhibitors reduce mitochondrial defects and toxicity caused by CHCHD10S59L mutations in human cells and Drosophila models.

This study investigates whether a 21-bp deletion mutant of Calpain 3 inhibits wild-type Calpain 3 activity and causes dominant toxicity in cell culture and Drosophila models, finding no inhibition of wild-type activity.

The paper shows that CHCHD10S59L causes mitochondrial toxicity in Drosophila and HeLa cells, which can be mitigated by inhibiting TDP-43 mitochondrial translocation or PINK1 kinase activity.