Nam Chul Kim

This study investigates JAG2-related muscular dystrophy by examining the role of Notch signaling in muscle stem cells, finding that JAG2 variants disrupt both autocrine and paracrine Notch signaling, impairing muscle regeneration.

The paper describes an undergraduate-led project using CRISPR/Cas9 to generate orange-eyed GAL4 lines in Drosophila by modifying the eye color phenotype of existing GAL4 lines.

The paper shows FDA-approved PDE4 inhibitors reduce mitochondrial defects and toxicity caused by CHCHD10S59L mutations in human cells and Drosophila models.

This study investigates whether a 21-bp deletion mutant of Calpain 3 inhibits wild-type Calpain 3 activity and causes dominant toxicity in cell culture and Drosophila models, finding no inhibition of wild-type activity.

The paper shows that CHCHD10S59L causes mitochondrial toxicity in Drosophila and HeLa cells, which can be mitigated by inhibiting TDP-43 mitochondrial translocation or PINK1 kinase activity.