M. Macias

Autophagy initiation triggers p150Glued-AP-2β interaction on the lysosomes to facilitate their transport.

This study shows that autophagy initiation promotes p150Glued-AP-2β interaction on lysosomes, enhancing their transport via dynein.

Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging

This study identifies impaired iron recycling by splenic red pulp macrophages as an early hallmark of aging and shows that reducing dietary iron improves iron turnover in aged mice.

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

Nutritional status and fecundity are synchronised by muscular exopheresis

The paper identifies exophers as muscle-derived vesicles that transfer yolk proteins to embryos, linking nutritional status to fecundity in C. elegans.

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.