B. Davidson

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

Tube2FEM: a general-purpose highly-automated pipeline for flow related processes in (embedded) tubular objects

This paper introduces a highly-automated pipeline for generating simulation-ready meshes of tubular structures, enabling CFD simulations across various biomedical and industrial applications.

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

Community health and human-animal contacts on the edges of Bwindi Impenetrable National Park, Uganda

This study examines human-animal contacts and health in a community near Bwindi Impenetrable National Park, identifying opportunities for cross-species pathogen transmission.

Design and validation of a multi-point injection technology for MR-guided convection enhanced delivery in the brain

This paper validates a multi-point injection cannula for MR-guided CED, showing improved volume distribution and reduced infusion time in brain phantoms.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.