Author

Z. Ai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

I. A. Udalova· 2 shared A. Clarke· 1 shared A. Cross· 1 shared A. E. Armitage· 1 shared A. E. Preston· 1 shared A. L. Corbin· 1 shared B. Galy· 1 shared B. M. Kessler· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

I. A. Udalova

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2 papers

Recent·Most cited

Plasma iron controls neutrophil production and function

J. N. Frost, S. K. Wideman, A. E. Preston, M. R. Teh, Z. Ai, L. Wang, A. Cross, N. White, Y. Yazicioglu, M. Bonadonna, A. Clarke, A. E. Armitage, B. Galy, I. A. Udalova, H. Drakesmith

The paper shows hypoferremia reduces neutrophil production and alters their function, while increasing NETosis, and suggests targeting hepcidin could modulate innate immunity.

bioRxiv · Mar 17, 2022Immunology

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages

G. Ryzhakov, H. Almuttaqi, A. L. Corbin, T. Khoyratty, D. Berthold, S. Bullers, H. L. Eames, Z. Ai, S. Bonham, R. Fischer, L. Jostins-Dean, S. P. L. Travis, B. M. Kessler, I. A. Udalova

This study identifies PYK2 as a key regulator of intestinal inflammation by activating IRF5 in macrophages, showing reduced inflammation in colitis models and human ulcerative colitis biopsies.

bioRxiv · May 24, 2020 · PreprintImmunology