PYK2 controls intestinal inflammation via activation of IRF5 in macrophages
G. Ryzhakov, H. Almuttaqi, A. L. Corbin, T. Khoyratty, D. Berthold, S. Bullers, H. L. Eames, Z. Ai, S. Bonham, R. Fischer, L. Jostins-Dean, S. P. L. Travis, B. M. Kessler, I. A. Udalova
This study identifies PYK2 as a key regulator of intestinal inflammation by activating IRF5 in macrophages, showing reduced inflammation in colitis models and human ulcerative colitis biopsies.
bioRxiv · May 24, 2020 · PreprintImmunology