BiochemistrybioRxiv
Investigating the NRAS 5' UTR as a Target for Small Molecules
S. Balaratnam, Z. R. Torrey, D. R. Calabrese…·J. S. Schneekloth
This study identifies a novel small molecule that binds to the NRAS mRNA G4 structure, showing in vitro translation inhibition but limited in vivo effects, highlighting transcript heterogeneity challenges.
DOI 10.1016/j.chembiol.2023.05.004