Cancer BiologybioRxiv
Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
K. Gnanapradeepan, S. Basu, T. Barnoud…·M. E. Murphy
This study shows that the p53 variant Pro47Ser increases mTOR activity and metabolic efficiency in mouse and human cells through altered redox regulation of Rheb.