Author

M. E. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:rat· 2

Frequent Co-Authors

A. M. Mitzey· 2 shared A. M. Weiler· 2 shared A. Mejia· 2 shared A. Possell· 2 shared A. S. Jaeger· 2 shared C. M. Crooks· 2 shared E. A. Brown· 2 shared E. L. Mohr· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. M. Mitzey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

B. Lipchick, A. N. Guterres, H.-Y. Chen, D. M. Zundell, S. Del Aguila, P. I. Reyes-Uribe, S. Basu, X. Yin, A. V. Kossenkov, Y. Lu, G. B. Mills, Q. Liu, A. R. Goldman, M. E. Murphy, D. W. Speicher, J. Villanueva

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

C. M. Crooks, A. M. Weiler, S. L. Rybarczyk, M. I. Bliss, A. S. Jaeger, M. E. Murphy, H. A. Simmons, A. Mejia, M. K. Fritsch, J. M. Hayes, J. C. Eickhoff, A. M. Mitzey, E. Razo, K. M. Braun, E. A. Brown, , M. T. Aliota

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

bioRxiv · Jan 25, 2021 · PreprintMicrobiology

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

C. M. Crooks, A. M. Weiler, S. L. Rybarczyk, M. I. Bliss, A. S. Jaeger, M. E. Murphy, H. A. Simmons, A. Mejia, M. K. Fritsch, J. M. Hayes, J. C. Eickhoff, A. M. Mitzey, E. Razo, K. Braun, E. A. Brown, , T. C. Friedrich

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

bioRxiv · Nov 30, 2020Microbiology

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

K. Gnanapradeepan, S. Basu, T. Barnoud, J. I.-J. Leu, M. Good, J. V. Lee, W. J. Quinn, C.-P. Kung, R. S. Ahima, J. A. Baur, K. E. Wellen, Q. Liu, Z. T. Schug, D. L. George, M. E. Murphy

This study shows that the p53 variant Pro47Ser increases mTOR activity and metabolic efficiency in mouse and human cells through altered redox regulation of Rheb.

bioRxiv · Feb 14, 2020Cancer Biology