Robert K. Ernst

This study shows human CASP4 and CASP5 form SMOCs in response to LPS structures that evade TLR4 and Casp11, revealing their distinct roles in sensing bacterial LPS and implications for sepsis therapy.

The paper identifies sigmaE as a key regulator of colistin heteroresistance in Enterobacter cloacae, showing that multiple regulatory systems are required for this resistance.

This study evaluates a novel TLR4 adjuvant, BECC470s, in enhancing rHA vaccination against H5N1 influenza in mice, showing improved antibody responses but limited cross-neutralizing activity.

This study identifies allelic variation in H. pylori cell surface genes that influence exoproteome binding and gastric tissue adherence through structural changes in lipopolysaccharide.

This study identifies two distinct mechanisms of colistin resistance in P. aeruginosa driven by magnesium depletion, each with different fitness costs.

MetaTracer assigns taxonomic and gene expression to metatranscriptomic reads using nucleotide alignment, achieving high accuracy in simulated and real datasets.

The paper investigates sex-dependent changes in insular cortex connectivity in a rat model of comorbid pain, finding increased insular-thalamo connectivity in female rats.

This study compares four Akkermansia species to identify adaptations to mucin-rich environments, finding unique protein expression and metabolite profiles in A. muciniphila.

This study evaluates BECC adjuvants' ability to enhance HA-based influenza vaccine efficacy in mice, showing improved immune responses and viral clearance.

The paper identifies site-selective lipid A modifications by PETs in E. coli, linking specific phosphate modifications to colistin resistance and fitness costs.

This paper applies non-negative matrix factorization to reduce and classify mass spectrometry imaging data in a visceral pain model, achieving high accuracy in distinguishing pain conditions.

This paper introduces a lipidomics-based method, FLAT, to rapidly identify negative urine cultures in UTI suspects with high accuracy, improving diagnostic efficiency.

This study determines the double bond position in Lipid A using ozone treatment on MALDI plates combined with tandem MS.

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.

The paper introduces RolDE, a new differential expression method for longitudinal proteomics data, which outperforms existing methods in handling missing values and reproducibility.